2025 ELLE Tweakment Award — Best for Jowls

The Future of
Non-Surgical
Aesthetics

Endolift® is the world's most advanced 1470nm diode laser platform for skin tightening, fat reduction, and facial sculpting — delivering surgical-level results with minimal downtime.

Add this FDA-cleared, Italian-engineered technology to your practice and unlock a new revenue stream with exceptional ROI. Free in-office training included.

See Patient Results
FDA Cleared
Made in Italy
All Skin Types I–VI
As Seen InMarie ClaireYahoo!AOLApple NewsVogue
Endolift procedure being performed
Technology
1470nm Diode Laser
How It Works

Precision Laser Energy.
Transformative Results.

Endolift® uses a micro-optical fiber — thinner than a human hair — inserted just beneath the skin's surface. The 1470nm wavelength is uniquely absorbed by both water and fat, making it the ideal dual-action tool for simultaneous skin tightening and lipolysis.

The controlled thermal energy stimulates deep collagen remodeling and elastin production, while precisely melting localized fat deposits that are naturally eliminated by the body over the following weeks.

Immediate Tightening
Visible lifting right after the procedure
Progressive Results
Collagen remodeling continues for 3–6 months
Minimal Downtime
Patients resume activities within 24–48 hours
Single Session
Most patients achieve goals in one treatment
Treatment Areas

Face, Neck & Body Contouring

Facial Sculpting

Precision Facial Contouring

Endolift® excels at treating the most common facial aging concerns with precision and control, delivering natural-looking results without the risks of surgery.

Jowls & Lower Face Laxity
Double Chin / Submental Fat
Nasolabial Folds & Marionette Lines
Cheek Contour & Mid-Face Lift
Brow Lifting
Under-Eye Area
Neck Tightening & Contouring
Jawline Definition
Body Sculpting

Total Body Transformation

Beyond the face, Endolift® delivers exceptional results for body contouring — targeting stubborn fat deposits and loose skin in areas that are notoriously difficult to treat.

Abdomen & Periumbilical Area
Upper Arms (Bat Wings)
Inner & Outer Thighs
Knees & Lower Legs
Flanks & Love Handles
Back & Bra Line
Buttocks Contouring
Post-Pregnancy Skin Laxity
Science & Evidence

How Endolift® Works:
Three Mechanisms, One Device

The 1470nm diode laser operates through three distinct, scientifically validated mechanisms — each contributing to the comprehensive rejuvenation and contouring results providers and patients expect.

1. Photobiomodulation → Neocollagenesis

The 1470nm wavelength is absorbed by cytochrome c oxidase in mitochondria, activating the electron transport chain and increasing ATP, ROS, and calcium ion production.

This cascade stimulates fibroblasts to synthesize new Type I and Type III collagen, progressively replacing degraded collagen with dense, organized bundles.

Result: Progressive skin tightening and dermal rejuvenation over 3–6 months.

2. Photothermal Contraction → Immediate Tightening

Controlled thermal energy causes immediate contraction of connective septa and collagen fiber retraction, creating visible lifting within minutes.

Elastic fibers remodel and realign, while tissue compaction creates sustained structural support.

Result: Immediate visible tightening and lifting effect right after the procedure.

3. Selective Lipolysis → Fat Reduction

The 1470nm wavelength is uniquely absorbed by both water and fat, enabling photothermal disruption of adipocyte membranes and triggering programmed cell death (apoptosis).

Released fat is naturally metabolized and eliminated via the lymphatic system over 4–12 weeks.

Result: Progressive fat reduction and body contouring without surgery.
Histological Evidence

Peer-Reviewed Clinical Validation

Histological studies confirm the biological mechanisms of Endolift® at the cellular level, demonstrating significant increases in collagen density, dermal thickness, and organized collagen bundle formation.

Histological analysis showing collagen remodeling
Collagen Remodeling
H&E staining showing dermal thickness changes
Sirius Red staining showing collagen density
Sirius Red Staining
Increased Type III collagen deposition
Laser-induced dermal remodeling patterns
Dense Collagen Bundles
Organized neocollagenesis at 20 J/cm²
Key Histological Findings
20 J/cm² dose induced dense, organized collagen bundles
Significant increase in dermal thickness at 3 and 6 months
Enhanced and more aligned elastin fibers (VVG staining)
Increased Type III collagen (Sirius Red staining)
Peer-Reviewed Citations

Bollero D, et al. In vivo pilot study of the effects of a subdermal 1470 nm diode laser on human skin. Laser Therapy. 2025;32(1). [Link]

Proietti I, et al. Synergistic Approach: Enhancing Facial Rejuvenation With Combined EndoliftX and Lightscan Therapy. J Cosmet Dermatol. 2025;24(7):e70344. [PMC]

Dompe C, et al. Photobiomodulation—Underlying Mechanism and Clinical Applications. J Clin Med. 2020;9(6):1724. [PMC]

Clinical Evidence

Real Results. Real Patients.

Peer-reviewed clinical studies demonstrate significant improvements in skin elasticity, dermal density, and wrinkle depth. Published in Skin Research & Technology (NIH/PMC), Endolift® showed a 26–44% improvement in key biometric parameters after a single treatment.

Before and after: Facial & Neck Lift
Before & After — Facial & Neck Lift
Facial & Neck LiftJowls + Neck
Before and after: Jawline Contouring
Before & After — Jawline Contouring
Jawline ContouringLower Face
Before and after: Full Face Rejuvenation
Before & After — Full Face Rejuvenation
Full Face RejuvenationFull Face
Before and after: Neck Tightening
Before & After — Neck Tightening
Neck TighteningNeck
Before and after: Body Contouring
Before & After — Body Contouring
Body ContouringThighs
Before and after: Facial Sculpting
Before & After — Facial Sculpting
Facial SculptingJawline + Neck
26–34%
Reduction in Wrinkle Depth
39–44%
Increase in Dermal Density
25%+
Improvement in Skin Elasticity
0
Severe Side Effects Reported

Source: Nilforoushzadeh et al., Skin Research & Technology, 2023 (PMC10523256). Results may vary.

Clinical Guidance

Patient Selection & Candidacy

Endolift® delivers optimal outcomes when matched to the right patient. Use these clinical criteria to identify ideal candidates and set realistic expectations.

Ideal Candidates

  • Mild to moderate skin laxity (Fitzpatrick laxity grade 1–3)
  • Submental / jowl fat with overlying skin laxity
  • BMI ≤ 30 (localized fat deposits, not generalized obesity)
  • All Fitzpatrick skin types I–VI
  • Ages 30–65 seeking non-surgical rejuvenation
  • Patients who want minimal downtime (24–48 hrs)
  • Those who have declined or are not ready for surgery
  • Post-weight-loss skin laxity (moderate)

Relative Contraindications

  • Active skin infection or open wounds in treatment area
  • Isotretinoin use within 6 months
  • Pregnancy or breastfeeding
  • Pacemaker or implanted electronic device (near treatment area)
  • Severe skin laxity (grade 4+) — may need surgical consult
  • BMI > 35 — suboptimal lipolysis outcomes
  • History of keloid or hypertrophic scarring
  • Autoimmune connective tissue disorders (e.g., scleroderma)

Skin Laxity Grading

Grade 1
Fine wrinkles at rest, minimal laxity
Excellent
Grade 2
Moderate laxity, early jowling
Excellent
Grade 3
Significant laxity, defined jowls
Good
Grade 4
Severe laxity, ptotic tissues
Adjunct

Grade 4 note: Consider combining with surgical consultation or using Endolift as a post-surgical maintenance protocol.

Anesthesia
Topical Only
EMLA or lidocaine cream 45–60 min prior
Procedure Time
30–90 Minutes
Depending on number of areas treated
Downtime
24–48 Hours
Mild swelling/bruising; social downtime only
Results Timeline
Immediate + 3–6 Mo
Visible lift day-of; peak collagen at 3–6 months
Business Case

Exceptional Return on Investment

With premium patient pricing and low consumable costs, Endolift® is one of the highest-margin procedures in aesthetic medicine today.

$3,500
Avg. Patient Charge (Face)
$500
Consumables Cost per Procedure
$3,000+
Estimated Profit per Procedure
1,000%+
ROI After Device Payoff
Treatment AreaAvg. Patient ChargeConsumables CostEstimated Profit
Full Face$3,000 – $4,000~$500$2,500 – $3,500
Face & Neck$3,500 – $5,000~$500$3,000 – $4,500
Jawline / Double Chin$2,000 – $3,000~$500$1,500 – $2,500
Body (Single Area)$3,000 – $5,000~$500$2,500 – $4,500
Arms / Abdomen$2,500 – $4,000~$500$2,000 – $3,500

* Pricing based on market research of U.S. aesthetic providers (2024–2025). Actual charges vary by market, provider, and patient complexity. Consumables cost reflects approximate per-procedure supply cost.

Device Payoff
17–33
Procedures to pay off the device
Monthly Revenue Potential
$30K+
Performing just 10 procedures/month
Long-Term ROI
1,000%+
Return on consumables after payoff
Provider Support

Free In-Office Training.
Complete Confidence.

We don't just sell you a device — we invest in your success. Our expert clinical trainers will come directly to your practice to provide hands-on, personalized training for you and your entire team.

Comprehensive Hands-On Training
Full-day in-office training covering patient selection, technique, protocols, and safety.
Whole-Team Certification
Training includes your medical staff, ensuring your entire team is confident and competent.
Marketing & Practice Growth Support
Access to before/after assets, patient education materials, and social media content.
Ongoing Clinical Support
Direct access to our clinical team for questions, complex cases, and continuing education.
Endolift provider training session
FREE
In-Office Training
Provider Voices

What Providers Are Saying

"Endolift has become one of the most requested procedures in my practice. Patients love that they can see results immediately and return to work the next day. The ROI has been exceptional."

Dr. Sarah M.
Board-Certified Dermatologist
New York, NY

"I was skeptical at first, but after seeing the clinical data and doing the training, I was sold. The results on my patients — especially for jowls and double chin — are genuinely impressive."

Dr. James T.
Aesthetic Medicine Physician
Miami, FL

"The training was thorough and our trainer was incredibly knowledgeable. We felt confident performing the procedure within the first week. It's been a game-changer for our med spa."

Jennifer K., NP
Medical Spa Owner
Dallas, TX
Get Started

Ready to Elevate
Your Practice?

Complete the form and our team will reach out within one business day with comprehensive pricing, device specifications, and to schedule a personalized consultation.

Comprehensive device pricing & financing options
Free in-office training for you and your team
Before/after photo library & marketing materials
Clinical protocols and patient selection guides
Ongoing support from our clinical team
Endolift laser device

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